APC Antibodies

AND APC ELISA kits, APC Proteins

Many biological assays use antibodies to detect APC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with APC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop APC antibodies...

We validate the specificity of these antibodies to APC by testing them on tissues known to express APC positively and negatively. Browse below to find the APC antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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APC Infographic by Boster Bio

All APC Products

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Product

Figures

Specificity

Applications

Price

Anti-APC Antibody

2 Citations 7 Q&As

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$399
Cat # A00008
100μl

Anti-APC Monoclonal Antibody

2 Citations 1 Q&As

Human, Mouse, Rat

IP, IF, IHC, ICC, WB

$370
Cat # M00008
100 μl

APC Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$480
Cat # EKC1034
1 kit, containing one 96-well plate and all necessary reagents

APC (Phospho-Ser2054) Colorimetric Cell-Based ELISA Kit

Human

ELISA

$540
Cat # EKC2213
1 kit, containing two 96-well plates and all necessary reagents

Anti-APC (phospho-S2054) Antibody

Human, Mouse, Rat

IHC, WB

$482
Cat # A00008S2054
100ul

APC Overview

Facts about Adenomatous polyposis coli protein.

Adenomatous polyposis coli protein (APC)

Tumor suppressor. APC activity is correlated with its phosphorylation state.

Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration.

Gene Information

Human
Gene Name:	APC
Uniprot:	P25054
Entrez:	324

Family

Belongs to:

adenomatous polyposis coli (APC) family

Alternative Names

adenomatosis polyposis coli tumor suppressor; adenomatosis polyposis coli; adenomatous polyposis coli protein; adenomatous polyposis coli; APC; BTPS2; Deleted in polyposis 2.5; DP2; DP2.5DP2; DP3; FPC; GS; Min; Protein APC

Molecular Weight

Mass (kDA):
311.646 kDA

Genomic Context


Human

Location:	5q22.2
Sequence:	5; NC_000005.10 (112707498..112846239)

Tissue Specificity

Expressed in a variety of tissues: brain, small intestine, colon, thymus, skeletal muscle, heart, prostate, lung, spleen, ovary, testis kidney, placenta, blood and liver (PubMed:21643010, PubMed:27217144). Isoform 1A: Very strongly expressed in brain but has relatively low expression levels in other tissues (PubMed:19527921, PubMed:21643010, PubMed:27217144). Isoform 1B: Predominant form in all tissues except for brain, including gastric mucosa and blood (PubMed:19527921, PubMed:21643010, PubMed:27217144).

Subcellular Localizations

Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm. Cell membrane. Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (PubMed:19151759). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854).

Diseases

Neoplasms
Malignant Neoplasms
Adenomatous Polyposis Coli
Polyposis
Colorectal Cancer
Carcinoma
Colorectal Neoplasms
Adenoma
Thrombosis
Cell Transformation, Neoplastic
Activated Protein C Resistance
Carcinogenesis
Inflammation

Malignant Tumor Of Colon
Tissue Adhesions
Polyps
Adenocarcinoma
Autoimmune Reaction
Colonic Neoplasms
Malignant Paraganglionic Neoplasm

Interacting Proteins

AMER1
AMER3
CDC42
CSNK1E
CTNNA1

CTNNB1
Ctnnb1
DVL1
DVL1P1
DVL2

JUP
KHDRBS1
LRP8
MAPRE1
SCRIB

SPATA13

Pathways

Coagulation
Immune Response
Cell Cycle
Cell Activation
Mitosis
Cell Proliferation
T Cell Activation
Methylation
Anaphase
Pathogenesis
Secretion
Localization
Proteolysis

T Cell Proliferation
Cytokine Production
Mismatch Repair
Metaphase
Cell Death
Cell Division
Dna Methylation

PTMs

Methylation
Phosphorylation
Cleavage
Ubiquitination
Dephosphorylation
Glycosylation
Reduction
Oxidation
Biotinylation
Acetylation

Demethylation
Carboxylation
Gamma-carboxylation
Ribosylation
Hydroxylation
Acylation
Iodination
Deglycosylation
Myristoylation
Sumoylation

Research Areas

Cancer
Cell Biology
Cell Cycle and Replication
Tumor Suppressors
Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APC

References

PMID: 1678319 by Joslyn G., et al. Identification of deletion mutations and three new genes at the familial polyposis locus.

PMID: 1651562 by Kinzler K.W., et al. Identification of FAP locus genes from chromosome 5q21.

2 Publications of Boster APC Antibodies & ELISA Kits

PubMed ID: 25608619, microRNA-146a inhibits cancer metastasis by downregulating VEGF through dual pat...
PubMed ID: 24194897, Li M, Tian L, Wang L, Yao H, Zhang J, Lu J, Sun Y, Gao X, Xiao H, Liu M. Plos On...

*More publications can be found for each product on its corresponding product page